Dr. Charles E. Novitski


Professional Training:

B.A., Columbia College, New York, NY, Biology. (Population genetics; Rifampicin mutants.)

Ph.D., California Institute of Technology, Pasadena, Biophysics, 1979. (Mitochondrial gene expression.)

Postdoc, City of Hope National Medical Center, Duarte, CA. (Systemic lupus erythematosis.)

Postdoc, Monash University, Clayton, Australia. (Mitochondrial mutant analysis in yeast.)

Lecturer, Monash University, Clayton, Australia. (Mitochondrial ATPase gene mutants.)

Program Leader, Nematode Control, Agrigenetics Advanced Sciences Company, Madison, WI.

Visiting Associate, California Institute of Technology, Pasadena. (Cell cycle timing of mt replication.)

Visiting Scientist, Leeds University, Leeds, UK. (Gene analysis of potato cyst nematode.)


Courses Being Taught Spring 2004:

Methods in Molecular Biology, Bio 597

Human Genetics, Bio 315

Eukaryotic Molecular Genetics Seminar, Bio 629b


Some Other Courses Taught:

Genetics, Bio 326

Molecular Biology and Recombinant DNA Technology, Bio 524

The Human Genome Project: The Science and Social Impliations, Bio 597

Human DNA Fingerprinting: DNA Proves Innocence, Bio 597

Eukaryotic Molecular Biology, Bio 610

Introduction to Biostatistics, Bio 500



Areas of Research Interest:

* Discovery of the Saccharomyces cerevisiae mitochondrial ATPase aap1 gene.

* Mutant sequence analysis of mitochondrial ATPase genes oli1 and oli 2.

* Sequence analysis of Peromyscus ATPase genes and origin of replication.

* Timing of mammalian mitochondrial DNA replication during the cell cycle.

* Gene family sequence structure for the major sperm proteins in plant-parasitic nematodes (Globodera).

* PCR detection test for the potato cyst nematode.

* Monoclonal antibodies against secretions of plant-parastitic nematodes in the root.

* Distinguishing Michigan Peromyscus species by PCR/RFLP analysis.

* Insights into Mendel's still enigmatic data, by statistical and computer simulation analysis.

* Identification of transgenic Huntington Disease mice.


Publications (and Patent):

Moran, P.A.P., Novitski, E., and Novitski, C.E. (1969) Parental age and the secondary sex ratio in humans. Annals of Human Genetics, 32: 315-316.

Latter, B.D.H. and Novitski, C.E. (1969) Selection in finite populations with multiple alleles. I. Limits to directional selection. Genetics, 62: 859-876.

Novitski, C.E. and Bajer, A.S. (1978) Interaction of microtubules and the mechanism of chromosome movement (zipper hypothesis), 3. Theoretical analysis of energy requirements and computer simulation of chromosome movement. Cytobios, 18: 173-182.

Vaughan, P.R., Woo, S.W., Novitski, C.E., Linnane, A.W., and Nagley, P. (1980) Cotransformation of yeast with mitochondrial DNA and a two micron based cloning vector. Biochem. International, 1: 610-619.

Macreadie, I.G., Choo, W.M., Novitski, C.E., Marzuki, S., Nagley, P., Linnane, A.W., and Lukins, H.B. (1982) Novel mitochondrial mutations between the oli2 and oxi3 genes affect the yeast mitochondrial ATPase. Biochem. International, 5: 129-136.

Nagley, P. and Novitski, C.E. (1982) Coding capacity of yeast mitochondrial DNA. Trends Biochem. Sci., 7: 281.

Novitski, C.E., Macreadie, I.G., Maxwell, R.J., Lukins, H.B., Linnane, A.W., and Nagley, P. (1983) Features of nucleotide sequences in the region of the oli2 and aap1 genes in the yeast mitochondrial genome. In Manipulation and Expression of Genes in Eukaryotes, (Nagley, P., Linnane, A.W., Peacock, W.J., and Pateman, J.A. Eds.) pp. 257-268, Academic Press, Sydney.

Macreadie, I.G., Novitski, C.E., Maxwell, R.J., John, U., Ooi, B.G., McMullen, G.L., Lukins, H.B., Linnane, A.W., and Nagley, P. (1983) Biogenesis of mitochondria: The mitochondrial gene (aap1) coding for mitochondrial ATPase subunit 8 in Saccharomyces cerevisiae. Nucl. Acids Res., 11: 4435-4451.

Linnane, A.W., Beilharz, M.W., McMullen, G.L., Macreadie, I.G., Murphy, M., Nisbet, I.T., Novitski, C.E., and Woodrow, G.C. (1984) Nucleotide sequence and expression in E. coli of a human interferon-a gene selected from a genomic library using synthetic oligonucleotides. Biochem. International, 8: 725-732. (Patent application submitted.)

Novitski, C.E., Macreadie, I.G., Maxwell, R.J., Lukins, H.B., Linnane, A.W., and Nagley, P. (1984) Biogenesis of mitochondria: Genetic and molecular analysis of the oli2 region of mitochondrial DNA in Saccharomyces cerevisiae. Current Genetics, 8: 135-146.

Ooi, B.G., McMullen, G.L., Linnane, A.W., Nagley, P., and Novitski, C.E. (1985) Biogenesis of mitochondrial DNA sequence analysis of mit- mutations in the mitochondrial oli1 gene coding for mitochondrial ATPase subunit 9 in Saccharomyces cerevisiae. Nucl. Acids Res., 13: 1327-1339.

Ooi, B.G., Novitski, C.E., and Nagley, P. (1985) DNA sequence analysis of the oli1 gene reveals amino acid changes in mitochondrial ATPase subunit 9 from oligomycin resistant mutants of Saccharomyces cerevisiae. Eur. J. Biochem., 152: 709-714.

Atkinson, H.J., Harris, P.D., Halk, E.L., Novitski, C.E., Leighton-Sands, J., Nolan, P., and Fox, P.C. (1988) Monoclonal antibodies to the soya bean cyst nematodes Heterodera glycines. Ann. Appl. Biol., 112: 459-469.

Novitski, C.E., Brown, S., Chen, R., Corner, A.S., Atkinson, H.J., and McPherson, M.J. (1993) Major sperm protein genes from Globodera rostochiensis. Journal of Nematology 25(4): 548-554.

Kulka, W.E. and Novitski, C.E. (1994) PCR Detection of Potato Cyst Nematodes, Globodera pallida and G. rostochiensis, using primers specific to the major sperm protein genes. Michigan Academician. XXVI: 479-485.

Novitski, C.E. (1995) A Closer Look at some of Mendel's Results. Journal of Heredity 86(1): 62-66.

Caldwell, L., and Novitski, C.E. (1998) DNA analysis for distinguishing among mice of the genus Peromyscus. Michigan Academician. XXX: 183-189.

Novitski, C.E. et al. (2004). Identification of Michigan Peromyscus species by mitochondrial D-loop sequence. In preparation.

Novitski, C.E. (2004). Revision of Fisher's analysis of Mendel's garden pea experiments. Genetics. 166, No. 3, 1139-1140.


Novitski, C.E., McLoughlin, T.J., and H.J. Atkinson (1993) U. S. Patent #5,264,210, issued November 23, 1993. Method for protecting plants from nematodes using P. cepacia. (Also Patent Application, European Patent Office, Application number 89306744.7.)


Contact Information:

Department of Biology, Central Michigan University

126 Brooks Hall, (517)774-6895, Charles.E.Novitski@cmich.edu

Office Hours (Spring 2004) : Monday 4:00 pm - 4:50 pm, Wednesday 4:00 pm - 4:50 pm, Friday 1:00 pm - 1:50 pm, or by appointment