8/26/2016: New Paper in Org. Biomol. Chem.
Sarah and Zac's paper, "Deoxyfluoro-D-trehalose (FDTre) analogues as potential PET probes for imaging mycobacterial infection," has been published in Org. Biomol. Chem. This paper describes synthetic chemistry and biochemistry that support the development of a trehalose-based nuclear imaging probe with possible tuberculosis diagnostic applications.
7/28/2016: Thesis Defense
Congratulations Lisa Meints on a successful M.S. thesis defense. Best of luck in the biomolecular sciences Ph.D. program at Michigan State University. We'll miss you!
The group in spring 2016 is pictured below, following a mini-golf and bowling day in mid-May.
We say goodbye to a number of wonderful friends and lab mates this summer. Hannah Foley, Max Hogue, Bailey Urbanek, and Sarah Rundell, who have been in the lab for 2-3 years each, will all receive their BS degrees from CMU and move on to bigger and better things. Hannah will join the chemistry Ph.D. program at the University of Michigan, while Sarah will begin a chemistry Ph.D. program at the Ohio State University. Bailey will start medical school at CMU, while Max will start dental school at University of Detroit-Mercy. We wish you all well.
3/29/2016: Student Awards
A number of our students received awards or recognition this semester. Congratulations to Hannah Foley, a senior biochemistry major who recently published as a co-first author in ACIE, for winning CMU's President's Award for Undergraduate Research and the Midland ACS Section Outstanding Undergraduate Biochemist award. Congrats to Brent Piligian, a junior biomedical sciences major who published as a co-first author in Chem. Commun., for receiving an Honorable Mention for the Barry Goldwater scholarship. Congrats to Sarah Rundell, a senior biochemistry major who has published in Chem. Commun. and ACIE, for winning department awards for Outstanding Organic Chemist and Outstanding Undergraduate Researcher (update, August 2016: Sarah also just published a co-first author paper in Org. Biomol. Chem. on her main project in the lab). Finally, congrats to Claudia Ramsey, a junior biomedical sciences major, for receiving a CMU Summer Scholars Award, which will support her research in the lab this summer.
3/23/2016: Upcoming Paper in JoVE
Lisa's paper, "Rapid One-Step Enzymatic Synthesis and All-Aqueous Purification of Trehalose Analogues," was accepted for publication in the Journal of Visualized Experiments (JoVE). We will be working with JoVE to develop a video protocol for this synthetic method.
1/06/2016: New Paper in ACIE
Hannah and Jessica's paper, "Bioorthogonal Chemical Reporters for Selective in Situ Probing of Mycomembrane Components in Mycobacteria," has been published in Angewandte Chemie International Edition. This paper describes a new set of chemical reporters that enable specific, sensitive, and simultaneous detection of the two major components of the mycobacterial outer membrane.
11/10/2015: New Lab Member
Welcome to our newest M.S. student, Taylor Fiolek, who completed his B.S. in biochemistry at CMU with Dr. Choon Lee.
110/26/2015: Conference Activity
A number of our students presented posters at local and regional meetings, including the Wayne State Graduate Symposium, the 11th Annual Midwest Carbohydrate and Glycobiology Symposium at Cleveland State University and the ACS Midland Section Fall Scientific Meeting at Saginaw Valley State University. Congratulations to Maxwell Hogue, Bailey Urbanek, and Brent Piligian for winning best poster awards!/p>
110/15/2015: New Paper in Chem. Commun.
Jessica and Brent's paper, "A Trifunctional Cyclooctyne for Modifying Azide-Labeled Biomolecules with Photocrosslinking and Affinity Tags," has been published in Chemical Communications. This paper describes a new bioorthogonal reagent that should facilitate the study of biomolecular interactions in live cells. Sarah Rundell also contributed.
008/31/2015: New Lab Members
We begin the semester with some new people in the lab, including undergraduates Claudia Ramsey and Tina Bednarz. Abi Detzler has now transferred to CMU and will be a permanent fixture in the lab during her undergraduate studies, and Tope Nathan has finished his B.S. in biochemistry and is now an M.S. student supported by a graduate fellowship from the Office of Graduate Studies and Research.